Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment

Authors

  • Hakob Atshemyan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204, Author
  • Naira Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204, Author
  • Artak Manukyan National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204 Author
  • Anush Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204 Author
  • Alvard Poghosyan Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014, Author

DOI:

https://doi.org/10.53411/jpadr.2022.3.2.7

Keywords:

adverse event, lymphoproliferative skin lesion, rifampicin resistant tuberculosis, mSTR treatment

Abstract

Case Presentation: This case report presents an unreported adverse event detected when conducting pharmacovigilance activity among the patients’ cohort receiving short, modified, all-oral treatment regimens (mSTR) for rifampicin-resistant tuberculosis (TB). Lymphoproliferative skin lesion was diagnosed histologically.

Results: The withdrawal clinical response and re-challenge positive test were detected, and the causal relationship was defined as “probable”.

 

Author Biographies

  • Hakob Atshemyan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

    mSTR Study Doctor,

  • Naira Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

    Deputy Director for Tuberculosis Control Programs,

  • Artak Manukyan, National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

    Director of the National Center for Pulmonology.

  • Anush Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

    Head of Data Management and Monitoring.

  • Alvard Poghosyan, Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014,

    Pathologist.

References

Margo, C. M., Crowson. A. N. (1996). Drug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates: A hypothesis. Human Pathology, 27(2), 125-132.

Novice, T., Ahn, J. W., Wilcox, R., Tejasvi, T., Hristov, A., & Mancuso, J. (2020). Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma. JAAD case reports, 6(4), 311–315.

WHO. 2013. The use of the WHO-UMC system for standardised case causality assessment. WHO Publications, 1-3. Retrieved from: https://www.who.int/publications/m/item/WHO-causality-assessment

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Published

2022-06-01

Issue

Vol. 3 No. 2 (2022): Journal of Pharmacovigilance and Drug Research

Section

Case Studies

License

Copyright (c) 2022 Hakob Atshemyan, Naira Khachatryan, Artak Manukyan, Anush Khachatryan, Alvard Poghosyan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment. (2022). Journal of Pharmacovigilance and Drug Research, 3(2), 34-37. https://doi.org/10.53411/jpadr.2022.3.2.7

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