Drug-drug interactions presenting as Bradyarrhythmia and Hyperkalaemia: A Case Report

Authors

  • Hirva S. Santoki Smt. N.H.L. Municipal Medical College, Ellisbridge, Ahmedabad Author
  • Sapna D. Gupta Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India Author
  • Shikha V. Sood Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India Author
  • Supriya D. Malhotra Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India Author

DOI:

https://doi.org/10.53411/jpadr.2022.3.4.6

Keywords:

Antihypertensive drugs, DDI, Diltiazem, Atenolol, ADR

Abstract

Introduction: Drug-drug interactions can be the major negative consequence while using a multidrug treatment approach. Hypertension is one of the preventable causes of cardiovascular disease. Treatment of hypertension is individualized based on the patient’s condition. Some patients may require simultaneous treatment with 4 to 5 anti-hypertensive drugs.

Case Details: We are presenting a case of a 69-year-old female patient, receiving 4 classes of antihypertensive drugs. Patient was admitted in our hospital with hyperkalemia and bradyarrhythmia. The patient had a history of being treated with Atenolol, Losartan, Hydrochlorothiazide, Diltiazem. Hyperkalaemia observed in this patient can be attributed to Losartan and Atenolol. Bradyarrhythmia can be the result of drug interaction between Diltiazem and Atenolol.

Conclusion: Physician should always keep in mind the interactions and adverse effects caused by medications used in treatment of Hypertension.

Author Biographies

  • Hirva S. Santoki, Smt. N.H.L. Municipal Medical College, Ellisbridge, Ahmedabad

    Department of Pharmacology, Resident doctor.

  • Sapna D. Gupta, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India

    Department of Emergency Medicine, Associate Professor.

  • Shikha V. Sood, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India

    Department of Pharmacology, Associate Professor.

  • Supriya D. Malhotra, Smt. N.H.L. Municipal Medical College, Ahmedabad, Gujarat, India

    Department of Pharmacology, Professor and Head.

References

Brunton LL. Goodman and Gilman’s The Pharmacological basis of Therapeutics. 13th ed. New York: McGraw-Hill Education; 2018.

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McKeever RG, Hamilton RJ. Calcium Channel Blockers. [Updated 2022 Jul 11]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482473/

McQuade, B. M., & Campbell, A. (2021). Drug Prescribing: Drug-Drug Interactions. FP essentials, 508, 25–32.

Mills, K. T., Stefanescu, A., & He, J. (2020). The global epidemiology of hypertension. Nature reviews. Nephrology, 16(4), 223–237.

JPADR Vol 3 No 4

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Published

2022-12-01

Issue

Vol. 3 No. 4 (2022): Journal of Pharmacovigilance and Drug Research

Section

Case Studies

License

Copyright (c) 2022 Hirva Santoki, Sapna Gupta, Shikha Sood, Supriya Malhotra

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Drug-drug interactions presenting as Bradyarrhythmia and Hyperkalaemia: A Case Report. (2022). Journal of Pharmacovigilance and Drug Research, 3(4), 32-34. https://doi.org/10.53411/jpadr.2022.3.4.6

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